Secrets of longevity: how biomarkers relate to life expectancy

Medical experts continue to explore the secrets of longevity, and recent discoveries in this area provide new data. A study from the Karolinska Institutet based on data from the population-based AMORIS cohort in Sweden provides valuable information on the relationship between biomarkers and life expectancy.

According to data published on the Springer Link portal, the purpose of the study was to compare the biomarker profiles of people who lived to 100 years with the profiles of their peers whose life expectancy was shorter. The researchers analyzed biomarker data measured between ages 64 and 99, looking at various aspects of metabolism, inflammation, liver and kidney function, and nutritional status. The total number of participants who have reached their 100th birthday is 1224 (84.6% of them are women).

Higher levels of total cholesterol and iron, and lower levels of glucose, creatinine, uric acid, aspartate aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, lactate dehydrogenase, and total iron-binding capacity were associated with reaching age 100 years.

It is noticeable that already from the age of 65, people who lived to be a century old had more favorable biomarker values ​​compared to those who died before this age. This observation may indicate that early changes in biomarkers may serve as predictors of longevity.

These results highlight the importance of understanding the relationship between biomarkers and lifespan. Although the mechanisms behind this connection require further study, they may open new pathways to prolonging healthy life and preventing age-related diseases.